MiniCD4 microbicide prevents HIV infection of human mucosal explants and vaginal transmission of SHIV(162P3) in cynomolgus macaques.
In complement to an effective vaccine, development of potent anti-HIV microbicides remains an important priority.We have previously shown that the miniCD4 M48U1, a functional mimetic of sCD4 Hockey Protective - Shoulder Pads - Youth presented on a 27 amino-acid stable scaffold, inhibits a broad range of HIV-1 isolates at sub-nanomolar concentration